Category Archives: Tumor Necrosis Factor-??

Non-classical monocytes are reported to arise by conversion of classical monocytes in the mouse. CD303 and CD304. Although not related directly to plasma cells they retain subtle lymphoid features and unique secretory properties. Homologues are recognized in many species. CD14+ DCs found in tissues and lymph nodes are a third subset of CD11c+ myeloid cells originally described as interstitial DCs. They are more monocyte-like or macrophage-like than CD1c+ and CD141+ mDCs and may arise from classical monocytes. Equivalent ARHGAP26 cells have recently been found in mice as a new monocyte-derived subset of CD11b classical DCs that expresses or ESAM. Langerhans cells (LCs) and microglia are two specialized self-renewing DC populations found in stratified squamous epithelium and parenchyma of the brain, respectively. The LCs are capable of differentiating into migratory DCs whereas microglia are considered as a type of macrophage by many authors. Recent reviews provide excellent summaries of microglia and…

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