Category Archives: Thymidylate Synthetase

´╗┐Shimizu K, Keller NP. cause of invasive aspergillosis (IA), a life-threatening invasive fungal illness in the ever-expanding populace of immunosuppressed individuals (1). While voriconazole represents the first-line therapy against IA, echinocandins (e.g., caspofungin) are an alternative treatment that may become more attractive, as the voriconazole resistance of is increasing (2). However, the antifungal activity of caspofungin against is limited by cell wall compensatory mechanisms resulting in antifungal tolerance (i.e., survival despite growth-inhibitory concentrations of the drug) (3, 4). Echinocandins’ lack of fungicidal activity against and the loss of effectiveness of caspofungin at higher concentrations (known as the paradoxical effect) may impact clinical results (5, 6). The molecular chaperone warmth shock protein 90 (Hsp90) was shown to be an important result in of resistance or tolerance GNE-4997 to caspofungin in yeasts and molds (7,C10). Genetic or pharmacologic inhibition of Hsp90 potentiates the antifungal activity of caspofungin against and abolishes the paradoxical…

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