Category Archives: trpc

´╗┐Supplementary MaterialsSupplemental Body 1 41416_2018_267_MOESM1_ESM. reduce breast cancer specific mortality but not the incidence of primary cancer. However, the means by which statins reduce mortality without affecting primary tumor development remains unclear. Methods We examine statin efficacy against two breast malignancy cell lines in models of NPI64 breast malignancy metastasis: a 2D in vitro co-culture model of breast cancer cell conversation with the liver, a 3D ex vivo microphysiological system model of breast cancer metastasis, and two impartial mouse models of spontaneous breast malignancy metastasis to the lung and liver, respectively. Results We demonstrate that statins can directly affect the proliferation of breast malignancy cells, specifically at the metastatic site. In a 2D co-culture model of breast cancer cell conversation with the liver, we demonstrate that atorvastatin can directly suppress proliferation of mesenchymal but not epithelial breast malignancy cells. Further, in an ex vivo 3D liver microphysiological system of breast…

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