Category Archives: Sigma2 Receptors

´╗┐Among different agents involved, anesthetics (e.g., isoflurane and sevoflurane) had been found to manage to a substantial HO-1 induction offering not merely an upregulation of HO-1, but organ protection also, while becoming clinically safe [20C22]. The pure compound of carbon monoxide itself may alter various diseases in all kinds of experimental physiological systems, settings, and target-organs (i.e., anti-inflammatory, anti-apoptotic, anti-oxidative, anti-proliferative, and vasodilative etc.); observe Fig. stimulus. With our growing understanding in the way CO exerts its effects, especially in the mitochondria and its intracellular pathways, it is appealing to speculate about a medical application of this compound. Since HO-1 is not easy to induce, study focused on the application of the gaseous molecule CO by itself or the implementation of carbon monoxide liberating molecules (CO-RM) to deliver the molecule at a time- and dose dependently safe way to any target organ. After years of study in cellular systems and…

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