Category Archives: TRPML

´╗┐Data Availability StatementThe writers concur that all data underlying the results are fully available without limitation. potential LC3-interacting area (LIR) motifs in PML are necessary for relationship of PML with LC3 while this association is certainly indie of autophagic activity. Finally, we show that interaction between LC3 and PML plays a part in cell growth inhibition function of PML. Due to the fact PML can be an essential tumor suppressor, we suggest that nuclear part of LC3 proteins may keep company with PML to regulate cell development for avoidance and inhibition of cancer occurrence and development. Introduction Promyelocytic leukemia (PML) gene was discovered as a fusion partner of human retinoic acid receptor alpha (RAR) TIC10 gene, resulting in PML-RAR fusion protein that is critical for pathogenesis of acute promyelocytic leukemia (APL) [1], [2], [3]. PML protein is usually characterized by presence of RBCC or tripartite motif (TRIM), which consists of…

Read more