Category Archives: Tachykinin NK1 Receptors

´╗┐Supplementary Materials1. failed to achieve functionality due to a lack of bioactivity and osteoinductive factors. In this study, we developed bioactive cell-derived ECM electrospun polycaprolactone (PCL) scaffolds produced from ECM derived from human mesenchymal stem/stromal cells (MSC), human umbilical vein endothelial cells (HUVEC) and their combination based on the hypothesis that this cell-derived ECM incorporated into the PCL fibers would enhance the biofunctionality of the scaffold. The aims of this study were to fabricate and characterize cell-derived ECM electrospun PCL scaffolds and assess their ability to enhance osteogenic differentiation of MSCs, envisaging bone tissue engineering applications. Our results demonstrate that cell-derived ECM electrospun scaffolds marketed significant cell proliferation in comparison to PCL by itself, while presenting equivalent physical/mechanised properties. Additionally, MSC:HUVEC-ECM electrospun scaffolds considerably improved osteogenic differentiation of MSCs as confirmed by elevated ALP activity and osteogenic gene appearance levels. To your knowledge, these outcomes describe the initial study recommending…

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