This oxysterol has been recently shown to be present in significant levels in the retina and RPE (Moreira et al
This oxysterol has been recently shown to be present in significant levels in the retina and RPE (Moreira et al., 2009) and to cause a variety of inflammatory GSK256066 2,2,2-trifluoroacetic acid reactions (Moreira et al., 2009andJoffre et al., 2007). By contrast, knockdown of MSRB2 by a miRNA in stably transfected cells did not convey increased level of sensitivity to the oxidative stress. In the monkey retina MSRB2 localized to the ganglion cell coating (GLC), the outer plexiform coating (OPL) and the retinal pigment epithelium (RPE). MSRB2 manifestation is definitely most pronounced in the OPL of the macula and foveal areas suggesting an association with the cone synaptic mitochondria. Our data suggests that MSRB2 takes on an important function in protecting cones from multiple type of oxidative stress and may become critical in GSK256066 2,2,2-trifluoroacetic acid conserving central vision. Keywords:retina, macula, methionine sulfoxide reductase B2, mitochondria, antioxidant == 1. Intro ==…