In the present study, because the number of split signals in PLS was extremely scarce compared with that of MLS/RC, we thought that the cases of PLS with a few split signals should not be recognized as a feature of MLS/RC
In the present study, because the number of split signals in PLS was extremely scarce compared with that of MLS/RC, we thought that the cases of PLS with a few split signals should not be recognized as a feature of MLS/RC. In some types of soft tissue and bone tumor, a chimeric fusion gene has been revealed which was not specific for an inherent histology.(15,16)Scotlandietal. sections of representative areas in all cases. Six of seven PLS cases showed theCHOPsplit signal ranging from 0.5% to 3% of counted nuclei, while all cases of MLS/RC exhibitedCHOPrearrangement in more than 50% of counted nuclei. All cases of PLS showed a varied distribution of extra signals with polyploidy and amplification in each histological area. NoCHOPfusion transcript was found in any case of PLS by nested RTPCR. ACHOPrearrangement in PLS should be recognized only as a representative part of complex karyotypes, because the number of…